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PubMed · 6928181

A convenient animal model for testing bone substitute materials.

J W Frame
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Abstract

There is consijerable interest in developing substitute materials for bone to perform the functions of autogenous bone grafts. However, a persistent problem is finding a suitable animal model in which to test the biodegradable implants. This paper reviews the requirements of an ideal animal model for this purpose and discusses the shortcomings of existing procedures. A technique is described that uses the cranial vault of the rabbit and allows accurate radiologic and histologic assessment of implant resorption and ingrowth of new bone.

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AnimalsBiocompatible MaterialsFemaleMaleParietal BoneRabbitsRadiographyTrephiningWound HealingJournal Article

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J W Frame. 1980. A convenient animal model for testing bone substitute materials.. https://pubmed.ncbi.nlm.nih.gov/6928181/

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