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PubMed · 6930029

Screening for malignant hyperthermia susceptibility.

I L Anderson·R E Rawstron·D J Dunlop
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Abstract

In vitro pharmacological testing of isolated muscle strips surgically removed under general anaesthesia from 10 members of a known MH family enabled identification of three MH positive individuals. Diagnosis of MH susceptibility was based on increased sensitivity to low concentrations of caffeine and the presence of halothane-induced contractures in MH susceptible muscle. Dantrolene sodium 15 mg/l completely prevented halothane-induced contractures in two muscle strips from one of the MH positive cases. The successful anaesthetic management of known MH patients is described, as is the successful management of a hyperthermic episode during recovery in one of the MH positive cases.

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CaffeineDantroleneHalothaneHumansMalignant HyperthermiaMass ScreeningMuscle ContractionMusclesJournal Article

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BibTeXRIS

I L Anderson, R E Rawstron, D J Dunlop. 1980-06-11. Screening for malignant hyperthermia susceptibility.. https://pubmed.ncbi.nlm.nih.gov/6930029/

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