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PubMed · 6937275

Human osteosarcoma-derived soluble bone morphogenetic protein.

F C Bauer·M R Urist
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Abstract

A bone morphogenetic protein (BMP) fraction obtained from the organic matrix of dentin is extractable from human osteosarcoma. A fresh en-bloc specimen excised from the femur of a 16-year-old boy was extracted with 4 M guanidine hydrochloride. The GuHCl-soluble, water-insoluble protein fraction induced new bone formation when implanted into the thigh muscles of athymic nude mice.

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AnimalsBone Morphogenetic ProteinsBone and BonesCartilageCollagenFemoral NeoplasmsGrowth SubstancesHumansHydroxyprolineMaleMiceMice, NudeNeoplasm ProteinsNeoplasm TransplantationOsteogenesisOsteosarcomaPeptidesProteinsTransplantation, HeterologousJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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F C Bauer, M R Urist. Human osteosarcoma-derived soluble bone morphogenetic protein.. https://pubmed.ncbi.nlm.nih.gov/6937275/

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