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GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning.

P Friedland·L Kedes·D Brutlag·Y Iwasaki·R Bach
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Abstract

We have built a knowledge-based genetic engineering simulation system-- GENESIS-- capable of representing both domain-specific and general knowledge. Information is stored within a hierarchically-organized framework composed of structures called units. A series of sophisticated editors enables no-computer specialist molecular geneticists to construct a knowledge base through direct interaction with the computer. Three types of knowledge specific to the domain of molecular genetics, MAPS, sequences and RULES are discussed in detail with examples.

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AnimalsBase CompositionBase SequenceComputersDNAGenesGenetic EngineeringGlobinsHistonesHumansMethodsSpecies SpecificityJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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P Friedland, L Kedes, D Brutlag, Y Iwasaki, R Bach. 1982-01-11. GENESIS, a knowledge-based genetic engineering simulation system for representation of genetic data and experiment planning.. https://doi.org/10.1093/nar%2F10.1.323

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