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PubMed · 6992076

Acute nonlymphocytic leukemia.

N L Kobrinsky·L L Robison·M E Nesbit
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Abstract

The discovery of cytosine arabinoside, and then the anthrocycline antibiotics, 6-thioguanine, vincristine, cyclophosphamide, and other drugs, has added to the armamentarium of known effective agents. The use of combination chemotherapy, the recognition of the need during induction for virtual marrow aplasia to obtain a remission, and recognition of the predilection of the disease for the central nervous system requiring prophylaxis constitute major advances. The impediment to long-term survival is the lack of effective maintenance therapy.

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Acute DiseaseAdolescentAgranulocytosisAntineoplastic AgentsCells, CulturedChildChild, PreschoolChromosome AberrationsChromosome DisordersDisseminated Intravascular CoagulationDrug Therapy, CombinationFemaleGraft vs Host ReactionHodgkin DiseaseHumansInfectionsLeukemiaLeukocytosisMaleMuramidasePreleukemiaThrombocytopeniaUric AcidJournal ArticleReview

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BibTeXRIS

N L Kobrinsky, L L Robison, M E Nesbit. 1980. Acute nonlymphocytic leukemia.. https://doi.org/10.1016/s0031-3955(16)33855-x

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