PubMed Health⌕ Search

PubMed · 699944

Chronic ventricular ectopic activity and sudden death.

Abstract

The majority of deaths from coronary heart disease (CHD) occur before the victims receive medical attention. Chronic ventricular ectopic activity (VEA) is a well-established predictor of coronary mortality as well as sudden death. Evidence that chronic VEA is independently and causally related to sudden death, however, remains equivocal. Only more advanced grades of chronic VEA appear to be significant. Arrhythmias are clearly more common in patients with advanced coronary obstruction, and therefore prone to new ischemic events and their associated electrical disturbances. Autopsy studies are limited in their ability to identify an acute myocardial infarction in patients who die suddenly, but experience with the mobile coronary care units has reemphasized the role of acute ischemia. The prospective, randomized trial, including reliable assessment of VEA, offers the only definitive means of identifying the contribution of chronic VEA to the incidence of sudden death from CHD.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

R Cooper. 1978. Chronic ventricular ectopic activity and sudden death.. https://pubmed.ncbi.nlm.nih.gov/699944/

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Safety of nerve conduction studies in patients with implanted cardiac devices.

Patients with implanted cardiac devices and their physicians may defer important electrodiagnostic testing because of anxiety about potential negative effects on the device. To determine the safety of routine nerve conduction studies (NCS) in this population, 10 patients with permanent dual-chamber pacemakers of various types and five patients with implanted cardiac defibrillators (ICD) underwent nerve stimulation at sites commonly used during NCS. The implanted cardiac device was interrogated before and after the study and there was continuous monitoring of the surface electrocardiogram (ECG) and atrial and ventricular electrograms. Electrical impulses generated during routine NCS were never detected by the sensing amplifier and did not affect the programmed settings of the implanted cardiac device. We conclude that routine NCS is safe in patients with implanted cardiac pacemakers with bipolar sensing configurations and defibrillators.

Arrhythmias, Cardiac↗

[Pulmonary diseases and heart function].

The most severe cardiac sequel to lung disease is the load on the right ventricle due to pulmonary hypertension with the development of a cor pulmonale. This is characterized by hypertrophy and/or dilatation of the right ventricle because of a primary impairment of lung function and/or lung structure. The most important pathomechanisms for the development of pulmonary hypertension are vessel obliteration, mechanical lesions, primary vascular or extra-vascular inflammation and hypoxic vasoconstriction. Chronic obstructive pulmonary disease (COPD) is one of the most important reasons for chronic cor pulmonale. A further very common reason is obstructive sleep apnea syndrome, especially if combined with a COPD. In this case, the prevalence of cor pulmonale can reach 80%. The development of a chronic cor pulmonale is the most striking negative prognostic factor for these patients. Only 30% of COPD patients with cor pulmonale survive longer than 5 years, and only early detection of the disturbances to respiration which might potentially lead to cor pulmonale and their subsequent therapy are able to improve the patient's prognosis. Furthermore, pulmonary diseases may also have an impact on the left heart side in terms of an impairment of left heart function or by inducing severe arrhythmias . Thus, lung diseases may have both a significant impact on right and left heart performance.

Arrhythmias, Cardiac↗