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PubMed · 7010704

Circulation immune complexes after renal transplantation.

B J Junor·A J d'Apice·P Kincaid-Smith
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Abstract

The liquid phase C1q-binding assay was used as a measure of circulating immune complexes in 147 renal transplant recipients. Thirty-six patients were studied serially from the time of transplantation. Abnormal levels of C1q-binding activity (C1qBA) were most frequently detected in the first 6 months post-transplant. Although there was a statistically significant association of elevated C1qBA with rejection, the incidence of "false positives" and "false negatives" was high and particularly evident in serial studies. There was no evidence of association between C1qBA and the recipients' original renal diseases. Post-transplant monitoring of renal transplant recipients for circulating immune complexes by the C1q-binding assay is an unreliable guide to rejection.

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Antigen-Antibody ComplexComplement Activating EnzymesComplement C1qFalse Negative ReactionsFalse Positive ReactionsFollow-Up StudiesGraft RejectionHumansKidneyKidney TransplantationTransplantation, HomologousComparative StudyJournal Article

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B J Junor, A J d'Apice, P Kincaid-Smith. 1980. Circulation immune complexes after renal transplantation.. https://doi.org/10.1097/00007890-198008000-00006

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