Cell-mediated hyperacute rejection. I. Acute, accelerated, and hyperacute reactions.

M Emam; E J Eichwald

doi:10.1097/00007890-198103000-00002

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Cell-mediated hyperacute rejection. I. Acute, accelerated, and hyperacute reactions.

M Emam·E J Eichwald

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Abstract

The morphology of first-set rejection of allogeneic murine skin grafts differs strikingly from that usually seen subsequent to sensitization. In the former, graft epithelium appears to be the primary target; in the latter, the endothelium of graft vessels. This difference suggests that different subsets of effector T cells may be involved. This paper reports an attempt to isolate, for further characterization, a T cell population associated with first-set rejection. The relationships between acute and hyperacute rejection of organ transplants and of murine skin grafts are discussed, as is the possible role of endothelium-specific antigens and receptors sites.

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Animals Female Graft Rejection Immunity, Cellular Immunity, Maternally-Acquired Immunization Lymphoid Tissue Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Skin Skin Transplantation Transplantation Immunology Transplantation, Homologous Journal Article Research Support, U.S. Gov't, P.H.S.

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M Emam, E J Eichwald. 1981. Cell-mediated hyperacute rejection. I. Acute, accelerated, and hyperacute reactions.. https://doi.org/10.1097/00007890-198103000-00002

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