Myoglobin function in exercising skeletal muscle.

R P Cole

doi:10.1126/science.7071598

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PubMed · 7071598

Myoglobin function in exercising skeletal muscle.

R P Cole

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Abstract

Short-term perfusion of the isolated dog gastrocnemius-plantaris muscle with hydrogen peroxide resulted in a decrease in steady-state muscle oxygen consumption and isometric tension generation. Hydrogen peroxide converted intracellular myoglobin to products incapable of combination with oxygen, but had no deleterious effect on neuromuscular transmission or on mitochondrial oxidative phosphorylation. It is concluded that functional intracellular myoglobin is important in maintaining oxygen consumption and tension generation in exercising skeletal muscle.

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Animals Dogs Hydrogen Peroxide Mitochondria, Muscle Muscle Contraction Muscles Myoglobin Oxidation-Reduction Oxygen Consumption Physical Exertion Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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R P Cole. 1982-04-30. Myoglobin function in exercising skeletal muscle.. https://doi.org/10.1126/science.7071598

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