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Initial methadone dose in treating opiate addiction.

R I Wang·C Kochar·A T Hasegawa·B L Roh
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Abstract

Intramuscular administration of naloxone was used to precipitate the narcotic withdrawal syndrome in opiate-dependent patients. Objective signs of withdrawal were rated according to a previously developed scale. Based upon naloxone-induced withdrawal scores, 76 patients were given a dose of methadone, either low, medium, or high, in a randomized double-blind manner on 2 consecutive days. The adequacy of the methadone dose was evaluated by assessing the patients' physical responses after each treatment. Results indicate that the medium dose of methadone in each naloxone-induced withdrawal score range provides optimal control of narcotic deprivation. It is concluded that a correct initial dose of methadone can be administered when the degree of opiate dependence is established by the naloxone test.

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Dose-Response Relationship, DrugDouble-Blind MethodHumansMethadoneNaloxoneNarcoticsOpioid-Related DisordersSubstance Withdrawal SyndromeClinical TrialJournal ArticleRandomized Controlled Trial

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R I Wang, C Kochar, A T Hasegawa, B L Roh. 1982. Initial methadone dose in treating opiate addiction.. https://doi.org/10.3109/10826088209071019

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