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PubMed · 7109828

Ionic shift in cerebral ischemia.

T Yanagihara·J T McCall
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Abstract

Electrolyte and water contents were measured in gerbil brain after unilateral cerebral ischemia. Increase of Na+ and water, and decrease of K+ occurred after an ischemic period of 30 minutes. However, these abnormalities disappeared within 3 hours. When the ischemic period was extended to 3 hours, the abnormalities observed after ischemia for 30 minutes were again encountered, but more significant alterations occurred immediately after re-establishment of blood flow. In addition to more pronounced increase of Na+ and decrease of K+, Ca2+ became significantly elevated after recirculation for 15 minutes and progressively increased during recirculation for 3 hours. The steady rise of Ca2+ appears to be related to the irreversibility of cerebral ischemia.

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AnimalsBody WaterBrainBrain IschemiaCalciumCarotid ArteriesElectrolytesGerbillinaeIschemic Attack, TransientKineticsMagnesiumPotassiumSodiumJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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T Yanagihara, J T McCall. 1982-05-31. Ionic shift in cerebral ischemia.. https://doi.org/10.1016/0024-3205(82)90473-8

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