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PubMed · 7122906

Early pregnancy-abortion model using sulprostone.

A Fleischer·H Schulman·P Blattner·N Jagani·A Fayemi
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Abstract

Sulprostone has been demonstrated to be effective as a parenteral abortifacient, but not as a vaginal suppository. A vaginal preparation was given to 19 women to determine its mechanism of action, and to confirm the principle of uterine conversion as a biological model for the induction of an early abortion. The drug was administered to women with confirmed pregnancies and amenorrhea and not exceeding 49 days. A 95% success rate was obtained with an incidence of drug related side effects of 20% as opposed to the general 80-90% figure of PGE2 and F2a. The hormone profile obtained revealed a parallel fall in hCG and estradiol, and progesterone. This study confirms the value of uterine conversion, a concept that describes the change in uterine reactivity following PG administration and determines the phase when uterine activity is no longer dependent on exogenous oxytocic medication.

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Abortion, InducedChemical PhenomenaChemistryChorionic GonadotropinDinoprostoneEstradiolFemaleHumansPregnancyPregnancy Trimester, FirstProgesteroneProstaglandins E, SyntheticSuppositoriesUterine ContractionVaginaAbortifacient AgentsAbortion, Drug InducedAge FactorsBiologyClinical ResearchContraceptionContraceptive MethodsDiarrheaEndocrine SystemEvaluationFamily PlanningFertility Control, PostconceptionGenitaliaGenitalia, FemaleGonadotropins, ChorionicNauseaParityPhysiologyProstaglandins--administraction and dosageResearch MethodologyUrogenital SystemUterine Effects--analysisUterusVaginal SpermicidesVaginal SuppositoryJournal Article

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A Fleischer, H Schulman, P Blattner, N Jagani, A Fayemi. 1982. Early pregnancy-abortion model using sulprostone.. https://doi.org/10.1016/s0090-6980(82)80004-x

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