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A quality assurance programme for quantitative urine analyses.

M D Shephard·L A Penberthy·C G Fraser
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Abstract

Eighty-six Australasian laboratories participated in an interlaboratory quality assurance programme for 10 urine analytes. Twelve liquid samples were prepared from commercial lyophilized urine control material and distributed in 3 batches of 4. Use of pre-set acceptability limits for total laboratory error and target values facilitated timely feedback in graphic form. The samples had concentrations which were linearly related; this allowed simple calculation of overall imprecision and bias, graphic feedback of all submitted results, and comparison of performance between laboratories. A number of unsuitable and poor methods were identified. Particular attention must be paid, in future, to more widespread use of appropriate calibration and quality control materials, to avoidance of transcription and calculation errors, and to analysis of urine samples with elevated levels of analyte. Current laboratory performance can meet analytical goals for analyses of urine creatinine, phosphate, urate, and glucose but analysis of urine sodium, potassium, urea, calcium, osmolality, and proteins require a significant improvement.

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M D Shephard, L A Penberthy, C G Fraser. 1982. A quality assurance programme for quantitative urine analyses.. https://doi.org/10.3109/00313028209061387

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