Enhanced radiation lethality in partially synchronized solid mouse tumors.

T Todoroki; S Koike; H Tsunemoto; I Watanabe

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PubMed · 7139626

Enhanced radiation lethality in partially synchronized solid mouse tumors.

T Todoroki·S Koike·H Tsunemoto·I Watanabe

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Abstract

We studied the combined effects of local irradiation on in vivo partially synchronized solid mouse tumors. Syngeneic fibrosarcoma cells were transplanted s.c. into the thighs of C3H/He mice. When the tumors grew to 179 cu mm in volume, 1-beta-D-arabinofuranosylcytosine (ara-C) was repeatedly injected i.p. followed by a single injection of vinblastine sulfate at 5 hr after the end of the ara-C treatment. The mitotic indexes increased from 4% in control to 22 to 23% at 5 hr after the ara-C treatment, and the level continued for another 5 hr. Further treatment with vinblastine sulfate after the ara-C injections resulted in more effective accumulation of mitotic cells, i.e., 30% at the sixth hr. The tumor was locally irradiated with a single dose of 3000 rads of gamma-rays at the maximum level of mitotic index. The results indicated a synergistic inhibition of tumor growth and an 84% prolongation of the 50% survival day beyond that of the nontreated control mice.

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Animals Cell Cycle Cell Line Cell Survival Cytarabine DNA Replication Female Fibrosarcoma Kinetics Male Mice Mice, Inbred Strains Mitotic Index Sarcoma, Experimental Journal Article Research Support, Non-U.S. Gov't

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T Todoroki, S Koike, H Tsunemoto, I Watanabe. 1982. Enhanced radiation lethality in partially synchronized solid mouse tumors.. https://pubmed.ncbi.nlm.nih.gov/7139626/

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