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PubMed · 7141815

Aqueous immune complexes in immunogenic uveitis.

E L Howes·D H Char·M Christensen
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Abstract

A primary immunogenic uveitis was produced in rabbits by the intravitreal injection of bovine plasma albumin or ovalbumin. A secondary or recurrent uveitis was induced by intravenous injection of the specific soluble antigen several months after the cessation of primary inflammation. Aqueous antigen-antibody complexes were studied at times of maximal clinical response in both primary and recurrent forms during resolution of primary immunogenic uveitis, and in a nonspecific protein extravasation induced by aqueous paracentesis. Immune complexes could be demonstrated only during times of clinically evident inflammation in immunogenic uveitis. The results indicate the importance of antigen-antibody complex formation in the pathogenesis of this form of experimental ocular inflammatory disease.

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AnimalsAntigen-Antibody ComplexAqueous HumorDisease Models, AnimalImmunity, CellularRabbitsUveitisJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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E L Howes, D H Char, M Christensen. 1982. Aqueous immune complexes in immunogenic uveitis.. https://pubmed.ncbi.nlm.nih.gov/7141815/

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