PubMed · 7171521
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S L Duncan. 1982. Menopausal flushing: where now?. https://doi.org/10.1111/j.1471-0528.1982.tb04648.x
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Five physiologic groupings of 45 EEG-sleep measures were acquired from serial 24-channel EEG-sleep recordings (i.e., sleep architecture, continuity, EEG spectral, phasic, and autonomic measures), utilizing 129 studies on 56 healthy preterm infants from 28 to 43 weeks postconceptional age (PCA) who were neurodevelopmentally normal on follow-up. Regression analyses chose the least number of measures that best reflected maturation. Four of 45 variables (i.e., spectral alpha energy during quiet sleep, total spectral EEG energy, arousal number during active sleep, and percentage of EEG discontinuity) most significantly explained brain maturation in neonates < 36 weeks PCA. Three of 45 variables (i.e., spectral theta and beta energies during active sleep and spectral alpha energy during quiet sleep) were most representative after 36 weeks PCA. Spectral EEG energies were the strongest indicators of maturation compared with other measures, particularly in near-term neonates.
Nitric oxide (NO) is a highly reactive free radical with a multitude of organ specific regulatory functions. Since 1985, NO has been the subject of numerous research efforts and as a result, has been found to play a major role in the cardiovascular, pulmonary, gastrointestinal, immune, and central nervous systems. In addition, deranged NO synthesis is the basis for a number of pathophysiologic states, such as atherosclerosis, pulmonary hypertension, pyloric stenosis, and the hypertension associated with renal failure. Traditional NO donors such as sodium nitroprusside and new pharmacologic NO adducts such as S-nitrosothiols may serve as exogenous sources of NO for the treatment of NO-deficient pathologic states. This review is an attempt to acquaint the surgical community with the fundamentals of NO biochemistry and physiology. Increased knowledge of its functions in normal homeostasis and pathologic states will enable physicians to better understand these disease processes and utilize new pharmacologic therapies.
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