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PubMed · 7187088

A simple method based on broken-line interpolation for displaying data from long-term clinical trials.

D J Gans
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Abstract

In displaying data from long-term clinical studies, variation across patients in the times at which readings are recorded often presents a problem. A simple method for treating such data is proposed, which avoids arbitrary conventions and methodological difficulties inherent in other approaches. It is based on within-patient broken-line interpolation, and is easy to implement on a computer. The method is tested and compared to others with computer-simulated data whose time-pattern is known. Though the comparison is of limited scope, the method appears to compare favourably with the 'closest-reading' and 'window' approaches.

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D J Gans. A simple method based on broken-line interpolation for displaying data from long-term clinical trials.. https://doi.org/10.1002/sim.4780010205

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