[New cerebrally active basic dithienyl compounds (author's tranls)].

K Thiele; K Posselt; H Offermanns; K Thiemer

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PubMed · 7190413

[New cerebrally active basic dithienyl compounds (author's tranls)].

K Thiele·K Posselt·H Offermanns·K Thiemer

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Abstract

A review on new cerebrally active basic dithienyl compounds related to (+)-(R)-alpha-((S)-1-[(3,3-di-3-thienylallyl)amino]-ethyl)-benzylalcohol (tinofedrine) is presented. Tinofedrine was selected out of a large number of related compounds on account of its high increase of cerebral blood flow, its improvement of heart performance, of the metabolism of the brain, and because it is well toleraded. Different routes of synthesis are discussed.

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Animals Benzyl Alcohols Benzyl Compounds Blood Viscosity Brain Chemistry Cardiac Output Cerebrovascular Circulation Chemical Phenomena Chemistry Dogs Structure-Activity Relationship Thiophenes Triglycerides English Abstract Journal Article

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K Thiele, K Posselt, H Offermanns, K Thiemer. 1980. [New cerebrally active basic dithienyl compounds (author's tranls)].. https://pubmed.ncbi.nlm.nih.gov/7190413/

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