Misonidazole and potentially lethal damage.

M Korbelik; B Palcic; K Skov; L Skarsgard

doi:10.1016/0360-3016(82)90661-7

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PubMed · 7201990

Misonidazole and potentially lethal damage.

M Korbelik·B Palcic·K Skov·L Skarsgard

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Abstract

The existence of potentially lethal damage (PLD) is demonstrated in exponentially growing CHO cells exposed to misonidazole in hypoxia. The method of hypertonic post-treatment of cells was used in these studies. Misonidazole-induced PLD differs in many characteristics from radiation-induced PLD. The repair kinetics of misonidazole-induced PLD are much slower than for the repair of radiation-induced PLD (hours vs. minutes). No significant repair of misonidazole-induced PLD took place at 25 degrees C. Other differences are discussed. Hypertonic post-treatment of irradiated cells which had been pre-incubated with misonidazole to non-toxic levels, gave survival data consistent with the interpretation that no radiation PLD can be induced in such cells.

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Aerobiosis Animals Cell Survival Cells, Cultured Cricetinae Cricetulus Female Hypoxia Misonidazole Nitroimidazoles Ovary X-Rays Journal Article Research Support, Non-U.S. Gov't

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M Korbelik, B Palcic, K Skov, L Skarsgard. Misonidazole and potentially lethal damage.. https://doi.org/10.1016/0360-3016(82)90661-7

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