Continuous positive-pressure ventilation does not alter ventricular pressure-volume relationship.

J E Fewell; D R Abendschein; C J Carlson; E Rapaport; J F Murray

doi:10.1152/ajpheart.1981.240.6.h821

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PubMed · 7246745

Continuous positive-pressure ventilation does not alter ventricular pressure-volume relationship.

J E Fewell·D R Abendschein·C J Carlson·E Rapaport·J F Murray

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Abstract

To determine whether alterations in the mechanical properties (i.e., stiffening) of the right and left ventricles contribute to the decrease in right and left ventricular end-diastolic volumes during continuous positive-pressure ventilation (CPPV), we studied six dogs anesthetized with chloralose urethane and ventilated with a volume ventilator. We varied ventricular volumes by withdrawing or infusing blood. Pressure-volume curves, constructed by plotting transmural ventricular end-diastolic pressures against ventricular end-diastolic volumes, did not change during CPPV (12 cmH2O positive end-expiratory pressure) compared to intermittent positive-pressure ventilation (IPPV, 0 cmH2O end-expiratory pressure). We conclude that decreased ventricular end-diastolic volumes during CPPV result primarily from a decrease in venous return. Alterations in the mechanical properties of the ventricles do not play a significant role in this response.

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Animals Blood Pressure Cardiac Output Dogs Heart Heart Rate Myocardial Contraction Pressure Surface Properties Ventricular Function Journal Article Research Support, U.S. Gov't, P.H.S.

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J E Fewell, D R Abendschein, C J Carlson, E Rapaport, J F Murray. 1981. Continuous positive-pressure ventilation does not alter ventricular pressure-volume relationship.. https://doi.org/10.1152/ajpheart.1981.240.6.h821

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