[Model system for studying thrombocyte interaction with the reconstructed vascular wall].

D D Sviridov; V L Leĭtin; E V Liubimova; O S Zakharova

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PubMed · 7259864

[Model system for studying thrombocyte interaction with the reconstructed vascular wall].

D D Sviridov·V L Leĭtin·E V Liubimova·O S Zakharova

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Abstract

A new model system is suggested which is a partial reconstruction of normal, locally and vastly injured vessel walls on the basis of fibrillar collagen grown cultures of endothelial cells. The kinetic curve of adhesion on collagen of gel-filtered human platelets reaches saturation within 40 min. During adhesion the shape of collagen bound platelets changes. Acetyl-salicylic acid and platelet free serum inhibit adhesion. Endothelial cells are nonadhesive to platelets; they do not affect the platelet adhesion to the intercellular areas covered with fibrillar collagen.

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Animals Blood Vessels Cattle Cells, Cultured Collagen Endothelium Humans In Vitro Techniques Kinetics Male Methods Microscopy, Electron, Scanning Models, Cardiovascular Platelet Adhesiveness English Abstract Journal Article

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D D Sviridov, V L Leĭtin, E V Liubimova, O S Zakharova. 1981. [Model system for studying thrombocyte interaction with the reconstructed vascular wall].. https://pubmed.ncbi.nlm.nih.gov/7259864/

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