Pattern recognition and time-dependent QSAR applied to morphinomimetic opioids.

P P Mager

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PubMed · 7270022

Pattern recognition and time-dependent QSAR applied to morphinomimetic opioids.

P P Mager

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Abstract

Pattern recognition and multivariate time-dependent structure-activity relationships were applied to a series of N-4-substituted 1-(2-arylethyl)-4-piperidinyl-N-phenylpropanamides. A correct classification of drugs to similar clusters requires identical results obtained from biological and chemical pattern recognition. The time point of the bioassay determines the significance of physicochemical features, and it was shown that substituent contributions vary within the time of bioassay.

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Analgesia Central Nervous System Depressants Chemical Phenomena Chemistry Computers Pattern Recognition, Automated Structure-Activity Relationship Time Factors Journal Article

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P P Mager. 1981. Pattern recognition and time-dependent QSAR applied to morphinomimetic opioids.. https://pubmed.ncbi.nlm.nih.gov/7270022/

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