Rapid decrease of precipitating and reaginic antibodies in Dirofilaria immitis-infected dogs which develop severe adverse reactions following treatment with diethylcarbamazine.

R S Desowitz; J W Barnwell; N E Palumbo; S R Una; S F Perri

doi:10.4269/ajtmh.1978.27.1148

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Rapid decrease of precipitating and reaginic antibodies in Dirofilaria immitis-infected dogs which develop severe adverse reactions following treatment with diethylcarbamazine.

R S Desowitz·J W Barnwell·N E Palumbo·S R Una·S F Perri

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Abstract

Dirofilaria immitis-infected dogs were treated with diethylcarbamazine. Measurement of the level of IgG precipitating antibody was carried out by counterimmunoelectrophoresis and that of IgE by passive cutaneous anaphylaxis in pre-treatment and post-treatment serum samples. In dogs showing severe to moderate adverse reactions to the drug there were pronounced decreases of both antibodies to a "metabolic" antigen prepared from the medium in which adult female worms had been incubated. These antibody levels did not decline in non-reacting dogs. Precipitating antibody levels to somatic antigens extracted from adult worms and microfilariae remained unaltered in both reactive and non-reactive animals.

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Animals Antibodies Diethylcarbamazine Dirofilaria immitis Dirofilariasis Dogs Filarioidea Journal Article

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R S Desowitz, J W Barnwell, N E Palumbo, S R Una, S F Perri. 1978. Rapid decrease of precipitating and reaginic antibodies in Dirofilaria immitis-infected dogs which develop severe adverse reactions following treatment with diethylcarbamazine.. https://doi.org/10.4269/ajtmh.1978.27.1148

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