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Atypical juvenile polyposis.

W F Grigioni·G Alampi·G Martinelli·A Piccaluga
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Abstract

Two cases of atypical juvenile polyposis are described in males of 9 months and 25 years-of-age. The first was associated with congenital megacolon and presented as juvenile polyps with features suggesting mild dysplasia. In the second case six histological lesions are found: I hyperplastic polyps; 2 juvenile polyps; 3 hyperplastic polyps with adenomatous areas; 4 juvenile polyps with areas of dysplastic epithelium; 5 adenomas; and 6 adenocarcinomas. On the basis of the morphological features we propose a pathogenetic sequence of focal mucosal hyperplasia to adenoma and carcinoma through stages of non-neoplastic and non premalignant polyps. Finally, the possibility that hyperplastic epithelium can in some circumstances have a greater dysplastic potential that normal colorectal mucosa is raised.

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AdenomaAdultColonColonic NeoplasmsHumansHyperplasiaInfantIntestinal MucosaIntestinal PolypsMaleMegacolonRectal NeoplasmsRectumCase ReportsJournal Article

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W F Grigioni, G Alampi, G Martinelli, A Piccaluga. 1981. Atypical juvenile polyposis.. https://doi.org/10.1111/j.1365-2559.1981.tb01798.x

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