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Vitamin E deficiency in Werdnig-Hoffmann disease.

Y Shapira·R Amit·E Rachmilewitz
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Abstract

Vitamin E levels were measured in the plasma of infants and children with various neuromuscular disorders. Seven of 8 infants with Werdnig-Hoffmann disease (WHD) had a significantly lower plasma vitamin E level (p less than 0.01) than age-matched normal controls, children with congenital myopathies, or children with muscular dystrophy. Vitamin E deficiency in WHD is not caused by malabsorption. A therapeutic trial of vitamin E in 3 patients with WHD did not change the natural course of the disease. Vitamin E deficiency may play a role in the pathogenesis of WHD.

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ChildChild, PreschoolHumansInfantMuscular AtrophyNeuromuscular DiseasesVitamin EVitamin E DeficiencyJournal ArticleResearch Support, Non-U.S. Gov't

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Y Shapira, R Amit, E Rachmilewitz. 1981. Vitamin E deficiency in Werdnig-Hoffmann disease.. https://doi.org/10.1002/ana.410100312

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