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PubMed · 7308956

[Determination of left ventricular function using nuclear medicine methods].

H Lichte
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Abstract

ECG-gated blood-pool scintigraphy with multiple gating acquisition is a good tool for evaluation of global and regional ventricular function. During exercise there is an average increase of ejection fraction of about 13.4% compared with rest ejection fraction in patients with normal ventricular function. A decrease or insufficient increase of ejection fraction by exercise is due to myocardial ischemia. After administration of isosorbiddinitrat in retard preparation there is an increase of ejection fraction of about 7%, lasting at least for 12 hours.

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Angina PectorisCoronary DiseaseElectrocardiographyHeart VentriclesHemodynamicsHumansIsosorbide DinitrateMyocardial ContractionMyocardial InfarctionRadionuclide ImagingJournal Article

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BibTeXRIS

H Lichte. 1981-12-03. [Determination of left ventricular function using nuclear medicine methods].. https://pubmed.ncbi.nlm.nih.gov/7308956/

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Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

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