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Retinol esterification in lamb kidney.

S Donoghue·K Johnson·W J Donawick·D Sklan
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Abstract

Retinol esterification was demonstrated in vivo and in vitro in lamb kidney. Retinol labeled with hydrogen-3 injected into the renal artery of lambs appeared in the labeled retinyl ester fraction in the renal vein. Degree of tracer incorporation into retinyl esters increased with vitamin A intake. In homogenates, activity was concentrated in microsomes and enhanced fourfold by addition of adenosine 5'-triphosphate and coenzyme A to the incubation mixture. These findings suggest that the esterification is a function of fatty acyl coenzyme A:retinol acyl transferase. Renal esterification may play a role in retinol homeostasis.

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AnimalsEsterificationFemaleInjections, Intra-ArterialKidneyLiverRenal ArterySheepVitamin AJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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S Donoghue, K Johnson, W J Donawick, D Sklan. 1981. Retinol esterification in lamb kidney.. https://doi.org/10.3168/jds.s0022-0302(81)82865-2

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