PubMed · 7344307
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J Kruszewski, A Szyszkowski, W W Jedrzejczak. [Adrenaline test: its practical application].. https://pubmed.ncbi.nlm.nih.gov/7344307/
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BACKGROUND: The serial plasma catecholamine response to exercise has not been studied fully in relation to left ventricular hypertrophy (LVH) in patients with hypertension (HT). This study determined whether plasma catecholamine responses to exercise are altered in essential HT in the presence or absence of LVH. MATERIALS AND METHODS: Plasma noradrenaline (NA) and plasma adrenaline (A) were measured at rest, during and after treadmill exercise in 59 hypertensive subjects and 22 age-matched control subjects. Patients were divided into LVH(-) (n = 20) and LVH(+) (n = 39) stratified by left ventricular mass index [LVMI: control subjects, LVH(-), LVH(+): 114 +/- 4, 105 +/- 3, 151 +/- 3 g m-2]. RESULTS: Exercise time (9.9 +/- 0.6, 7.6 +/- 0.7, 7.3 +/- 0.6 min) was shorter in patients with HT. Both systolic and diastolic blood pressures were higher in patients with HT, and no difference was observed between LVH(-) and LVH(+) patients. Resting plasma NA was not different (157 +/- 16, 173 +/- 17, 167 +/- 14 pg mL-1), but plasma NA at stage I (300 +/- 30, 342 +/- 40, 469 +/- 40 pg mL-1) was higher in LVH(+) patients than in LVH(-) patients or control subjects. Plasma A response to exercise was similar among the three groups. There was a positive correlation (r = 0.38, P < 0.001) between LVMI and Deltaplasma NA at stage I in all subjects. CONCLUSIONS: Patients with essential HT with LVH had augmented plasma NA response during submaximal exercise, whereas patients without LVH did not exhibit this augmentation. The positive correlation between LVMI and Deltaplasma NA suggested a possible association between the degree of cardiac hypertrophy and sympathetic activation during exercise.
Catecholamines content was measured in blood plasma and urine in 104 patients presenting with different neurological syndromes of vertebral osteochondrosis. The results secured were compared to the values of vegetative cardiovascular tests in the same patients. Patients presenting with reflex vegetative muscular-and-tonic, reflex vegetovascular manifestations of vertebral osteochondrosis, and those patients presenting with radix symptomatology as well as those patients with reflex neurodystrophic manifestations (though less evident in the latter) were all diagnosed as having developed relatively high values for blood plasma content of norepinephrine at the expense of degeneration of peripheral vegetative nerve endings and reduction of the normal recapture of this mediator from the blood and its urine elimination. Diagnosing of high values for blood plasma and urine content of norepinephrine against the background of a striking inhibition of indices of vegetative cardiovascular tests in patients with vertebrogenic radix symptomatology suggest involvement into the bodily process of compensation and adaptation of suprasegmental vegetative nerve structures.