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PubMed · 7345126

[Exercise echocardiography: relationship between interventricular septal wall dynamics and electrocardiographic changes during ischemia (author's transl)].

H Naito·M Matsuzaki·Y Takahashi·Y Matsuda·H Ogawa·T Sasaki·T Uchida·T Takahashi·T Kumada·R Kusukawa
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Abstract

The relationship between interventricular septal (IVS) wall motion assessed by the echocardiogram and surface electrocardiogram was investigated in 11 patients (pts) with proximal left anterior descending coronary artery disease (LADd) during ergometer exercise. A specially devises transducer was used to obtain the echocardiograms. During exercise, 6 pts had transient ST segment depression (Group 1), whereas 5 pts had transient ST segment elevation (Group 2). During exercise-induced ischemia, the ST segment depression occurred prior to abnormal wall motion in Group 1, and lasted longer than the latter. On the other hand, the ST segment elevation was preceded by abnormal wall motion in Group 2, and returned to the control earlier than the latter. In conclusion, exercise echocardiography is useful to assess the relationship between interventricular wall dynamics and electrocardiographic changes during ischemia.

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Angina PectorisEchocardiographyElectrocardiographyFemaleHeart SeptumHumansMaleMiddle AgedPhysical ExertionEnglish AbstractJournal Article

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BibTeXRIS

H Naito, M Matsuzaki, Y Takahashi, Y Matsuda, H Ogawa, T Sasaki, T Uchida, T Takahashi, T Kumada, R Kusukawa. 1981. [Exercise echocardiography: relationship between interventricular septal wall dynamics and electrocardiographic changes during ischemia (author's transl)].. https://pubmed.ncbi.nlm.nih.gov/7345126/

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Effect of a hypoglycemic agent on ischemic preconditioning in patients with type 2 diabetes and stable angina pectoris.

OBJECTIVE: Ischemic preconditioning is an increased tolerance to myocardial ischemia during the second of two consecutive exercise tests. ATP-sensitive K(+) channel blockers, such as glinides and sulfonylurea drugs, can induce loss of ischemic preconditioning. This study aimed to investigate the effects of repaglinide, a hypoglycemic agent with an affinity for myocardial ATP-sensitive K (+)channels, on the results of consecutive exercise tests in patients with diabetes and multivessel coronary artery disease. METHODS: Forty-two patients with type 2 diabetes and chronic stable angina pectoris, and two-vessel or three-vessel disease participated in this study. The patients underwent two consecutive treadmill exercise tests (phase 1). On the day after these exercise tests, 2 mg of oral repaglinide was given to the patients. One week later, two exercise tests were repeated consecutively (phase 2). RESULTS: All patients achieved 1.0-mm ST-segment depression during the four exercise tests (T1, T2, T3, and T4). In phase 2, seven patients improved in time to onset of 1.0-mm ST-segment depression. The worsening of the time to onset of 1.0-mm ST-segment depression in phase 2 demonstrated ischemic preconditioning block in 83.3% of patients (P=0.0001). Even the postexercise electrocardiographic parameters (ST-segment depression morphology and magnitude and arrhythmias) were significantly different between the groups with and without pharmacologic ischemic preconditioning block (P=0.031). CONCLUSIONS: Repaglinide, an oral hypoglycemic agent with ATP-sensitive K(+) channel-blocker activity, eliminated the myocardial ischemic preconditioning in patients with coronary disease and diabetes.

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