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PubMed · 7378106

A highly topically active corticosteroid. Preliminary report.

Y Mizushima·H Miyake·K Fujiwara·N Ono·K Takikawa
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Abstract

The local anti-inflammatory effects of a synthetic corticosteroid, 17 alpha, 21-diacetory-2-bromo-6 beta, 9 alpha-difluoro-11 beta-hydroxy-1,4,-pregnadiene-3,20-dione (F-2), were evaluated by granuloma and granuloma pouch method. F-2 had an intensive and probably persistent topical anti-inflammatory activity. The systemic effects of F-2 were evaluated by measuring the thymus and adrenal gland weight. F-2 did not induce significant systemic effects at as high a dose as 125 times the effective dose.

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Y Mizushima, H Miyake, K Fujiwara, N Ono, K Takikawa. 1980. A highly topically active corticosteroid. Preliminary report.. https://pubmed.ncbi.nlm.nih.gov/7378106/

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