Methaqualone RIA structure versus reactivity.

Abstract

Fourteen different methaqualone-related substances (substituted 2-methyl-3-phenyl-4-quinazolinones) were analyzed by radioimmunoassay (RIA) at several different concentrations. An attempt is made to relate structural differences to the affinity of the compounds for the Roche RIA methaqualone antibody. The effects of substituent placement on the 2-methyl-3-phenyl-4-quinazolinone molecule are studied. Addition of a group to the para-position of the 3-phenyl group increased affinity, but alteration of other key functional groups had a reverse effect.