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PubMed · 7415217

Xenobiotic triglyceride formation.

J V Crayford·D H Hutson
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Abstract

1. When 3-phenoxy[14C]benzoic acid was dosed orally (0.76 mg/kg) to rats, 1--3% of the administered radioactivity was found in the skin four days after dosing. Approximately 90% of this residue was unchanged 3-phenoxybenzoate, 10% was a neutral compound. 2. The residue in the skins of rats dosed with 193 mg of 3-phenoxybenzoic acid over 7 days (c. 100 mg/kg per day) contained 40% 3-phenoxybenzoate and 60% neutral metabolites. 3. The components were separated and purified by gel permeation, absorption and t.l.c. and analysed by mass spectrometry. 4. 2- and 3-(3-Phenoxybenzoyl)dipalmitins were major components of the neutral metabolite.

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AnimalsBiotransformationDose-Response Relationship, DrugFemaleHydrogen-Ion ConcentrationMalePharmaceutical PreparationsRatsSkinTriglyceridesJournal Article

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J V Crayford, D H Hutson. 1980. Xenobiotic triglyceride formation.. https://doi.org/10.3109/00498258009033767

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