GABAB receptors.

D I Kerr; J Ong

doi:10.1016/0163-7258(95)00016-a

Home/Archive/PubMed

PubMed · 7494864

GABAB receptors.

D I Kerr·J Ong

View original source ↗Export metadata ↓

Abstract

GABAB receptors are a distinct subclass of receptors for the major inhibitory transmitter 4-aminobutanoic acid (GABA) that mediate depression of synaptic transmission and contribute to the inhibition controlling neuronal excitability. The development of specific agonists and antagonists for these receptors has led to a better understanding of their physiology and pharmacology, highlighting their diverse coupling to different intracellular effectors through Gi/G(o) proteins. This review emphasises our current knowledge of the neurophysiology and neurochemistry of GABAB receptors, including their heterogeneity, as well as the therapeutic potential of drugs acting at these sites.

Explore related subjects

Baclofen Binding, Competitive Cations, Divalent Central Nervous System Central Nervous System Diseases GABA Agonists GABA Antagonists GTP-Binding Proteins Humans Neurophysiology Radioligand Assay Receptors, GABA-B Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

Keep this discovery

Explore connections, maps & timelines

BibTeX RIS

D I Kerr, J Ong. 1995. GABAB receptors.. https://doi.org/10.1016/0163-7258(95)00016-a

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Intrathecal catheter granuloma with baclofen infusion.

Explore the source record for details and available documents.

Baclofen↗

PubMed2006

Enteral baclofen in the management of tetanus-related spasms: case report and review of literature.

We report here the successful use of baclofen administered by nasogastric route in a 3.5-year-old child with tetanus, whose spasms were not controlled even with high dose of midazolam infusion.

Baclofen↗

PubMed2006

[Efficacy of intrathecal baclofen in the treatment of spasticity in stroke].

OBJECTIVE: To determine whether intrathecal administration of baclofen reduced spastic hypertonia in a hemiplegic patient after hemorrhagic stroke. METHODS: A trial of intrathecal administration of baclofen was carried out with bolus injections of 50 and 75 microg baclofen and clinical and functional evaluation (Aschworth, articular amplitude) before and after injection in a patient with hemorrhagic stroke. After these trials, the placement of a pump was proposed to the patient. RESULTS: Aschworth score improved from 4 to 3 on triceps, quadriceps and adductus, with functional improvement of gait quality and perimeter and position in the wheelchair. Cephalgia, present before the treatment, increased after the implantation of the pump. The patient had some ejaculation trouble with the treatment, as well as some neurological pains after the pump implantation but experienced no effect on upper limbs. DISCUSSION: The intrathecal administration of baclofen has been used in some studies of hemiplegic patients, with reduced spasticity and improved the kinematic parameters of gait. The intrathecal baclofen administration could complement other treatment to control spasticity after stroke. CONCLUSION: Intrathecal baclofen administration could be an interesting complementary therapeutic among patients with important spasticity not controlled by the usual treatments.

Baclofen↗