PubMed · 7501929
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T Vallot, G Cadiot. 1995. [Ranitidine: consequences on secretory function and gastric mucosa].. https://pubmed.ncbi.nlm.nih.gov/7501929/
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Gastric carcinoids are rare neuroendocrine tumors, usually classified as type I, if associated with atrophic body gastritis; type II, if associated with Zollinger-Ellison syndrome and multiple endocrine neoplasia type I, and type III, in the absence of any gastric pathology (sporadic tumors). The pathological features, as well as the prognosis of the tumor and the patient's survival strictly depend on this classification. The correct management of the patient with gastric carcinoid can only be proposed when the tumor has been classified by an accurate pathological and clinical evaluation of the patient. While the therapeutic approach in types I and II is based on a conservative strategy, including endoscopic resection, an adequate follow-up program, and the possible use of somatostatin analogues, an aggressive surgical approach is required in type III.
Gustatory and anticipatory cephalic stimuli that are detected during a meal yield nutritional information and aid in the efficient digestion of food. It is possible that animals can detect the amount of dietary food and its quality via cephalic relay to initiate proper digestion in the alimentary tract. The abdominal vagus conveys primary afferent nutritional information from the digestive system to the brain and modulates gastrointestinal motor and secretory activity that ensures the food digestion through local and central reflexes. Almost all the 5-HT in the body exists in the enterochromaffin (EC) cells in the alimentary tract, but the physiological significance of the mucosal 5-HT is not well elucidated. In the present paper, we reviewed recent advances in studies on gut nutrient perception and proposed the hypothesis that 5-HT derived from EC cells acts as a general transmitter of gut nutrient sensing by the abdominal vagus.
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