Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood.

M Havel; F Grabenwöger; J Schneider; G Laufer; G Wollenek; A Owen; P Simon; H Teufelsbauer; E Wolner

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PubMed · 7510351

Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood.

M Havel·F Grabenwöger·J Schneider·G Laufer·G Wollenek·A Owen·P Simon·H Teufelsbauer·E Wolner

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Abstract

Forty-five male patients with planned coronary artery bypass operation were randomized in a double blind fashion to receive either 6 million kallikrein inactivator units of aprotinin (high-dose group), 2 million kallikrein inactivator units of aprotinin (low-dose group), or placebo (control group). Postoperative bleeding was significantly decreased in both aprotinin groups in comparison to that in the control group (590 ml [290 to 1800 ml] high-dose group and 650 ml [280 to 1900 ml] low-dose group versus 920 ml (350 to 2700 ml) control group, p < 0.001). There was no difference between the two aprotinin groups. The need for postoperative blood transfusion was significantly lower in the aprotinin groups (1.46 [0 to 4] blood units high-dose group and 1.65 [0 to 5] blood units low-dose group versus 2.43 [0 to 7] blood units control group, p < 0.05). All patients underwent coronary angiography between the seventh and twelfth postoperative day. No difference was found among the three groups in patency of vein grafts-93.8% in the high-dose group, 94.5% in the low-dose groups, and 93.3% in the control group. Therefore, aprotinin significantly reduced postoperative bleeding and transfusion requirement after coronary artery bypass grafting without influencing early graft patency.

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Aprotinin Blood Transfusion Coronary Angiography Coronary Artery Bypass Double-Blind Method Graft Occlusion, Vascular Hemorrhage Humans Male Middle Aged Postoperative Complications Time Factors Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

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M Havel, F Grabenwöger, J Schneider, G Laufer, G Wollenek, A Owen, P Simon, H Teufelsbauer, E Wolner. 1994. Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood.. https://pubmed.ncbi.nlm.nih.gov/7510351/

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