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PubMed · 7526274

Circulating soluble adhesion molecules in systemic vasculitis.

A A Pall·D Adu·M Drayson·C M Taylor·N T Richards·J Michael
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Abstract

The plasma levels of soluble intercellular adhesion molecule-1 (sICAM-1), E-selectin (sE-selectin), and vascular cell adhesion molecule-1 (sVCAM-1), might reflect endothelial activation and injury and would therefore be useful markers of disease activity in vasculitis. To investigate this we measured the levels of sICAM-1, sE-selectin, and sVCAM-1 by two-site ELISAs in the plasma of patients with (a) active vasculitis (n = 16), (b) vasculitis in remission (n = 15), (c) chronic renal failure (CRF) (n = 10), and (d) normal healthy controls (n = 10). Plasma sICAM-1 levels were significantly higher in patients with active vasculitis, 323 ng/ml (193-607) compared with patients with inactive vasculitis, 199 ng/ml (131-297); P = 0.0006 and healthy controls, 188 ng/ml (138-259); P = 0.0002. Plasma sE-selectin levels were also significantly higher in the patients with active vasculitis, 45 ng/ml (15-65) compared with patients with inactive vasculitis, 25 ng/ml (15-55); P = 0.027 but not when compared with healthy controls, 35 ng/ml (20-55); P = 0.16. There was no difference in plasma sVCAM-1 levels between patients with active vasculitis, OD 0.56 (0.45-0.85) and inactive disease, OD 0.58 (0.47-0.79) (P = 0.12) or with healthy controls OD 0.49 (0.42-0.68) (P = 0.48). There were no significant differences between the plasma levels of any of the soluble adhesion molecules between patients with active vasculitis and patients with chronic failure.(ABSTRACT TRUNCATED AT 250 WORDS)

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C-Reactive ProteinCell Adhesion MoleculesCreatinineE-SelectinEnzyme-Linked Immunosorbent AssayHumansIntercellular Adhesion Molecule-1Kidney Failure, ChronicLeukocyte CountNephelometry and TurbidimetryRheumatoid FactorSolubilityVascular Cell Adhesion Molecule-1Vasculitisvon Willebrand FactorJournal Article

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A A Pall, D Adu, M Drayson, C M Taylor, N T Richards, J Michael. 1994. Circulating soluble adhesion molecules in systemic vasculitis.. https://pubmed.ncbi.nlm.nih.gov/7526274/

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