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Immunologic tolerance: development and disruption.

W O Weigle
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Abstract

Loss of tolerance to self-antigens is thought to have a role in a variety of common diseases. Studies in animal models of such diseases as systemic lupus erythematosus have provided new insights into how self-tolerance is broken or bypassed and how it may be restored. These and other experiments also are clarifying how self-tolerance is normally established; the T lymphocyte appears to be the dominant player.

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AnimalsAntigen PresentationAutoimmune DiseasesAutoimmunityClonal AnergyClonal DeletionHumansSelf ToleranceT-Lymphocytesgamma-GlobulinsCommentJournal ArticleReview

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W O Weigle. 1995-02-15. Immunologic tolerance: development and disruption.. https://doi.org/10.1080/21548331.1995.11443152

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