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PubMed · 7587163

A personal computer-based system for parallel line analysis of bioassay data.

N Iznaga·G Núñez·J Solozabal·A Morales·E Artaza·R Rubio·E Cardenas
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Abstract

A program is described for symmetric parallel line analysis of bioassay data with a logistic dose-response relationship. Dose-response relationship is transformed to semilog or log-log. A regression line can be calculated for the dose-response curve for standard and test samples, and produces potency estimate of test sample preparation relative to the standard preparation based on parallel-line bioassay statistical methods [3,4], together with detailed analysis of variance, estimates of slope, intercept and chi 2 test which permits a very sensitive test for linearity and parallelism of standard and test sample and facilitates detection of 'outliers', i.e. samples exhibiting non-parallelism. The general comparison of dose-response relationships produced by the program are a feature of particular interest.

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Analysis of VarianceBiological AssayBlood CoagulationChi-Square DistributionComputer GraphicsData DisplayData Interpretation, StatisticalDose-Response Relationship, DrugMathematical ComputingMicrocomputersModels, TheoreticalRegression AnalysisSoftwareJournal Article

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N Iznaga, G Núñez, J Solozabal, A Morales, E Artaza, R Rubio, E Cardenas. 1995. A personal computer-based system for parallel line analysis of bioassay data.. https://doi.org/10.1016/0169-2607(95)01648-d

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