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Raf-1 is activated during mitosis.

A D Laird·S J Taylor·M Oberst·D Shalloway
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Abstract

The Raf-1 serine/threonine kinase transmits proliferative and developmental signals to downstream effectors in the mitogen-activated protein kinase cascade. Studies to date have concentrated on its role in growth factor-mediated activation of the cell cycle. We show here that Raf-1 kinase activity is also highly stimulated during mitosis, with an attendant distinctive electrophoretic mobility shift due to hyperphosphorylation. These results suggest that Raf-1 may play a role in traversal of at least two distinct phases of the cell cycle.

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3T3 CellsAnimalsCell CycleEnzyme ActivationMiceMitosisPhosphorylationPlatelet-Derived Growth FactorProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-rafJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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A D Laird, S J Taylor, M Oberst, D Shalloway. 1995-11-10. Raf-1 is activated during mitosis.. https://doi.org/10.1074/jbc.270.45.26742

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