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Transdermal hormonal replacement therapy with transdermal progestin every second month.

R Lindgren·B Risberg·M Hammar·G Berg
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Abstract

OBJECTIVES: Unopposed estrogen therapy may induce endometrial hyperplasia. To protect the endometrium, estrogen replacement therapy should be combined with a progestin in menopausal women with an intact uterus. The aim of this open non-comparative study was to evaluate the effects on bleeding control and endometrium of 'spacing-out' the 14-day progestin therapy to every second month during transdermal combined hormonal replacement therapy. METHODS: Sixty-eight healthy women, previously treated with sequential combined transdermal hormonal replacement therapy every month for 3 years, were treated for the following 2 years in cycles with 6 weeks of transdermal estradiol 50 micrograms/daily (Estraderm, Ciba-Geigy), followed by 2 weeks of combined norethisterone acetate 0.25 mg/day and 50 micrograms estradiol per day. RESULTS: Annual endometrial biopsies diagnosed hyperplasia in one woman during the second year whereas most biopsies showed a secretory endometrium. Vaginal ultrasound showed no correlation to either bleeding-pattern or histopathological diagnosis. Most women had a regular bleeding-pattern. CONCLUSIONS: Transdermal progestin every second month might be an alternative to regular monthly sequential hormonal replacement therapy.

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Administration, CutaneousBiopsyClimactericDose-Response Relationship, DrugDrug Administration ScheduleEndometriumEstradiolEstrogen Replacement TherapyFemaleHumansMiddle AgedNorethindroneNorethindrone AcetateJournal Article

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BibTeXRIS

R Lindgren, B Risberg, M Hammar, G Berg. 1995. Transdermal hormonal replacement therapy with transdermal progestin every second month.. https://doi.org/10.1016/0378-5122(95)00913-6

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