PubMed · 7770719
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
R Andersson. 1995. Small colorectal polyps.. https://doi.org/10.3109/00365529509093279
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
Colorectal cancer arises from a precursor lesion, the adenomatous polyp, which forms in a field of epithelial cell hyperproliferation and crypt dysplasia. Progression from this precursor lesion to colorectal cancer is a multistep process, accompanied by alterations in several suppressor genes that result in abnormalities of cell regulation, and has a natural history of 10-15 years. Environmental factors and inherited susceptibility play major roles in this sequence of events. As a result of familial and genetic studies, we now have a better understanding of various high-risk groups and the application of screening methods to these individuals and to people at average risk. In the future, further identification of genetically predisposed individuals and colonoscopic screening of the general population may provide new opportunities for control of colorectal cancer through secondary prevention, and a better understanding of lifestyle factors and their modification will lead to improved strategies for primary prevention.
Use of a nylon tissue biopsy bag at the suction port during snare colonoscopic polypectomy refines our previously reported technique in which we used a 4-inch x 4-inch gauze pad. The nylon tissue biopsy bag results in superior pathologic specimens, maintains simplicity of the technique, and is cost effective.
A number of recent publications dealing with colon polyps and cancer emphasize cost-effectiveness and the outcomes of screening and follow-up surveillance of high-risk groups. These groups include patients with either a past personal history or a family history of colorectal adenomas or cancer. Several papers address the effectiveness and compliance with different methods of screening of the asymptomatic, average-risk population for colorectal neoplasia. Other important publications deal with colorectal cancer prevention, the natural history of the adenoma-carcinoma sequence, diagnosis of polyps and cancer, colonoscopic polypectomy, management of the patient with a malignant polyp, and endoscopic treatment of obstructing cancer.