A new flush solution for extended lung preservation.

W Wisser; H Ringl; T Wekerle; E Wolner; W Klepetko

PubMed · 7779848

A new flush solution for extended lung preservation.

W Wisser·H Ringl·T Wekerle·E Wolner·W Klepetko

Abstract

BACKGROUND: The aim of this study was to compare the effect of the most frequently used clinical preservation solution (Euro-Collins, group I) with a newly composed low potassium, glucose- and insulin-containing preservation solution (141 mmol/L sodium, 6.4 mmol/L potassium, 119 mmol/L chloride, 5 mmol/L magnesium, 10 gm/L glucose, 10 gm/L dextrane and 20 U/L insulin) (group II) on postischemic lung function. METHODS: We studied 12 isolated New Zealand White rabbit lungs in a closed circuit model during the first 4 hours of reperfusion after 24 hours of ischemic hypothermic storage. RESULTS: Oxygenation capacity, defined by the difference between the arterial and venous oxygen tension was significantly higher in group II compared with group I after 10 (58.7 +/- 5.8 versus 34.9 +/- 7.5 mm Hg), 30 (63.5 +/- 7.8 versus 27.3 +/- 10.4 mm Hg) and 180 minutes (77.7 +/- 7.2 versus 8.8 +/- 5.6 mm Hg). Ventilatory pressure was significantly lower in group II after 1 minute (11.3 +/- 1.3 mm Hg versus 13.7 +/- 0.5 mm Hg, p < 0.05), with no significant difference thereafter. No significant difference was found in pulmonary vascular resistance except after 20 minutes (30.8 +/- 1.2 dyns/cm5 [group I] versus 27.1 +/- 1.1 dyns/cm5 [group II], p < 0.05). CONCLUSION: These data suggest that this new solution provides superior lung function after 24 hours ischemic time compared with Euro-Collins solution.

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Animals Hydrogen-Ion Concentration Hypertonic Solutions Lung Lung Transplantation Organ Preservation Rabbits Reperfusion Solutions Time Factors Comparative Study Journal Article Research Support, Non-U.S. Gov't

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W Wisser, H Ringl, T Wekerle, E Wolner, W Klepetko. A new flush solution for extended lung preservation.. https://pubmed.ncbi.nlm.nih.gov/7779848/

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