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PubMed · 7797948

In vitro T cell function, delayed-type hypersensitivity skin testing, and CD4+ T cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus.

M J Dolan·M Clerici·S P Blatt·C W Hendrix·G P Melcher·R N Boswell·T M Freeman·W Ward·R Hensley·G M Shearer
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Abstract

Human immunodeficiency virus type 1 (HIV-1)-infected patients (n = 335) in the US Air Force HIV Natural History Program were followed for 3 years (mean) after skin testing, immunophenotyping of CD4+ cell subsets, and measurement of in vitro interleukin-2 production after stimulation by phytohemagglutinin, alloantigens, tetanus toxoid, and influenza A virus. The T cell functional assay predicted survival time (P < .001) and time for progression to AIDS (P = .014). Skin testing for tetanus, mumps, and Candida antigen and the total number of positive tests (P < .001 for each) stratified patients for survival time. In a multivariable proportional hazards model, the T cell functional assay (P = .008), the absolute number of CD4+ T cells (P = .001), the percentage of CD4+ CD29+ cells (P = .06), and the number of reactive skin tests (P < .001) predicted survival time. Thus, cellular immune functional tests have significant predictive value for survival time in HIV-1-infected patients independent of CD4+ cell count.

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Acquired Immunodeficiency SyndromeAdultCD4 Lymphocyte CountCD4-Positive T-LymphocytesFemaleHIV InfectionsHumansHypersensitivity, DelayedImmunity, CellularMaleMiddle AgedMilitary PersonnelMultivariate AnalysisPredictive Value of TestsPrognosisProportional Hazards ModelsSkin TestsSurvival RateT-LymphocytesTime FactorsUnited StatesComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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M J Dolan, M Clerici, S P Blatt, C W Hendrix, G P Melcher, R N Boswell, T M Freeman, W Ward, R Hensley, G M Shearer. 1995. In vitro T cell function, delayed-type hypersensitivity skin testing, and CD4+ T cell subset phenotyping independently predict survival time in patients infected with human immunodeficiency virus.. https://doi.org/10.1093/infdis%2F172.1.79

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