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Preimplantation genetics: a case for prospective action.

E Pergament·A Bonnicksen
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Abstract

Preimplantation genetics describes a newly-emerging field in medical genetics, the consequence of the implementation of clinical preimplantation diagnosis and the likely future development of germ-line gene therapy. Given the existing clinical and laboratory difficulties already demonstrated in preimplantation diagnosis and the sensitive ethical issues surrounding genetic manipulation of human embryos, there is a need for 1) critical and objective evaluation of developments in this field by human and medical geneticists and 2) development of guidelines for research and clinical practice in the years ahead. We propose a course of prospective action for preimplantation genetics implemented through the newly-formed American College of Medical Genetics in order to address the ethics, safety, accuracy, cost, and overall merit of preimplantation genetics.

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Advisory CommitteesBlastocystDiagnostic ErrorsEmbryo ResearchEthics, MedicalFederal GovernmentFetal DiseasesGenetic Diseases, InbornGenetic EnhancementGenetic TherapyGenetics, MedicalGuidelines as TopicHealth PolicyHumansMoral ObligationsPolicy MakingPrenatal DiagnosisResearchResource AllocationRisk AssessmentSafetySocial Control, FormalSocial ResponsibilitySocieties, MedicalUnited StatesAmerican College of Medical GeneticsBiomedical and Behavioral ResearchGenetics and ReproductionHuman Embryo Research PanelNational Advisory Board on Ethics in Reproduction (NABER)National Institutes of HealthJournal ArticleResearch Support, Non-U.S. Gov't

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E Pergament, A Bonnicksen. 1994-08-15. Preimplantation genetics: a case for prospective action.. https://doi.org/10.1002/ajmg.1320520206

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