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Hemodialysis--projecting future bed needs. Deterministic and probabilistic forecasting.

J S Pliskin·T I Steinman·E G Lowrie·C H Beck
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ComputersHealth Facility PlanningHealth Facility SizeHospital Bed CapacityHumansKidney TransplantationModels, TheoreticalProbabilityRenal DialysisTissue DonorsTransplantation, HomologousJournal Article

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J S Pliskin, T I Steinman, E G Lowrie, C H Beck. 1976. Hemodialysis--projecting future bed needs. Deterministic and probabilistic forecasting.. https://doi.org/10.1016/0010-4809(76)90054-9

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Molecular orbital study on the glutathione-dependent detoxication of ozonides.

The present paper describes a theoretical study on the mechanism underlying the reaction of cellular glutathione (GSH) with polyunsaturated fatty acid ozonides. The reaction can be catalyzed by glutathione S-transferases and leads to detoxication of the ozonides. Semi-empirical molecular orbital computer calculations suggest that the reaction of glutathione with ozonides involves a nucleophilic attack at one of the carbon atoms of the ozonide ring, instead of at one of the peroxidic oxygen atoms of the ozonide ring. This implies a mechanism different from that of the glutathione S-transferase-mediated reaction with hydroperoxides, previously proposed for the glutathione-dependent detoxication of fatty acid ozonides.

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