PubMed · 7885942
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G Schmidt, G E Morfill. 1994. Complexity diagnostics in cardiology: methods.. https://doi.org/10.1111/j.1540-8159.1994.tb02383.x
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Recent advances in high-resolution ultrasonography combined with color-coded Doppler analysis have enabled a new insight to be gained into fetal physiology and allowed the investigation of small, previously inaccessible fetal vessels under normal and abnormal conditions. In addition, the findings in some cases contradict the accepted fetal pathophysiology derived from animal studies. The aim of the present study is to describe new reports assessing the major compartments of the fetal cardiovascular system (heart, lung, splanchnic and fetal venous circulations) and to discuss the developments in these fields.
The authors studied physiologic peculiarities associated with cardiorespiratory response to hypoxia and hypercapnia in various climate and geographic conditions, to combined effects of hypoxia, hypercapnia and physical burden, in artificial atmosphere with various velocity of hypoxia and hypercapnia increase. The studies were based on a hypothesis of universal mechanism that describes regulation of gas-transporting system and is aimed to supply oxygen to the body under ecologic hazards. The authors revealed similarity of circulatory and respiratory responses to hypoxia and hypercapnia in various ecologic circumstances.
The Nobel Prize for Medicine and Physiology 1998 was awarded to three American pharmacologists: Robert F.Furchgott, Louis J. Ignarro and Ferrid Murad for their work on nitric oxide as a signalling molecule in the cardiovascular system. This discovery is a classical case of serendipity. NO is an endothelium-derived factor which mediates local vasodilation. It protects the vascular system against atherosclerosis by various effects on leukocytes and vascular permeability. NO appears to be a universal signalling molecule in the body, involved in the inflammatory response, apoptosis and neurotransmission. Its biochemistry is closely linked to that of oxygen radicals.