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PubMed · 7901586

Endogenous complement C3 synthesis in immune complex nephritis.

S H Sacks·W Zhou·P A Andrews·B Hartley
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Abstract

Human renal epithelial and mesangial cells have been shown to synthesise complement C3 in culture, but the relevance of this finding to the development of complement-mediated nephritis is uncertain. We investigated C3 gene expression in tissue biopsies that showed three main categories of renal injury. By semiquantitative polymerase chain reaction, biopsies from patients with immune-complex glomerulonephritis and those with cell-mediated interstitial nephritis showed increased C3 expression (p < 0.05), but biopsies from patients with non-immune glomerular injury did not. These findings suggest that local C3 production is enhanced in immune-mediated nephritis and are consistent with the hypothesis that locally synthesised complement components are involved in the pathogenesis of tissue injury.

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Complement C3cCulture TechniquesGene ExpressionHumansImmune Complex DiseasesKidney CortexNephritisPolymerase Chain ReactionRNA, MessengerJournal ArticleResearch Support, Non-U.S. Gov't

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S H Sacks, W Zhou, P A Andrews, B Hartley. 1993-11-20. Endogenous complement C3 synthesis in immune complex nephritis.. https://doi.org/10.1016/0140-6736(93)92362-w

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