Leucocytoclastic vasculitis induced by prolonged exercise.

M Prins; J C Veraart; A H Vermeulen; R F Hulsmans; H A Neumann

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PubMed · 8736335

Leucocytoclastic vasculitis induced by prolonged exercise.

M Prins·J C Veraart·A H Vermeulen·R F Hulsmans·H A Neumann

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Abstract

Many people develop skin symptoms after long-distance walks, but little is known about the aetiology of these. In this study we took 11 biopsies from 10 long-distance walkers who walked 80 km. All biopsies originated from purpuric lesions on the lower legs, which had appeared during walking. In all 11 specimens, signs of a leucocytoclastic vasculitis were present with leucocytoclasis, exocytosis of erythrocytes and a granulocyte/mononuclear perivascular infiltrate. Immunofluorescence investigations showed deposition of C3c in many specimens and immunoglobulin M in some. The occurrence of a leucocytoclastic vasculitis after prolonged exercise may be explained by the existence of an exercise altered cutaneous microcirculation, complement activation and an altered immune function.

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Complement C3c Erythema Female Humans Immunoglobulin M Leg Dermatoses Male Purpura Vasculitis, Leukocytoclastic, Cutaneous Walking Journal Article

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M Prins, J C Veraart, A H Vermeulen, R F Hulsmans, H A Neumann. 1996. Leucocytoclastic vasculitis induced by prolonged exercise.. https://pubmed.ncbi.nlm.nih.gov/8736335/

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