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The Wellcome Lecture, 1992. Cell cycle control.

P Nurse
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Abstract

Genetic analysis using the fission yeast has provided a powerful methodology to investigate the eukaryotic cell cycle and its control. The onset of M-phase in fission yeast is controlled by a regulatory gene network which activates the p34cdc2 protein kinase encoded by the cdc2+ gene. The coupling of M-phase to the completion of S-phase also works through p34cdc2. A similar network is operative in vertebrate cells. Future work will focus on the controls regulating onset of S-phase and on the mechanisms by which a cell duplicates itself in space during division.

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AnimalsAwards and PrizesCDC2 Protein KinaseCell CycleDNA ReplicationDNA, FungalGenes, FungalHumansMitosisS PhaseSchizosaccharomycesUnited KingdomVertebratesJournal ArticleResearch Support, Non-U.S. Gov'tReview

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P Nurse. 1993-09-29. The Wellcome Lecture, 1992. Cell cycle control.. https://doi.org/10.1098/rstb.1993.0127

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