Granuloma annulare: direct immunofluorescence study.

P Umbert; R K Winkelmann

doi:10.1111/j.1365-2133.1976.tb00858.x

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Granuloma annulare: direct immunofluorescence study.

P Umbert·R K Winkelmann

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Abstract

Direct immunofluorescence studies were carried out in eleven specimens of granuloma annulare. The results (in all cases) indicate the presence of focal deposition of fibrin, localized primarily in the intervascular portion of the dermis, corresponding to the granulomatous and necrobiotic areas. These findings implicate the cellular mechanism of delayed hypersensitivity with focal involvement of the clotting system in the development of granuloma annulare lesion.

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Blood Coagulation Complement C3 Fibrin Fluorescent Antibody Technique Granuloma Humans Hypersensitivity, Delayed Immunity, Cellular Immunoglobulin M Necrobiosis Lipoidica Sarcoidosis Skin Skin Diseases Journal Article

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P Umbert, R K Winkelmann. 1976. Granuloma annulare: direct immunofluorescence study.. https://doi.org/10.1111/j.1365-2133.1976.tb00858.x

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